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INSULIN HUMAN, ISOPHANE (NPH) 100 UI/ml, 10ml, vial N

https://medicalguidelines.msf.org/en/node/824
https://unicat.msf.org/cat/product/11716
STD DINJINSHI1VN

Valid Article

Former Code(s): DINJINSH1VI DINJINSHI1V
The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
18.5.1 - Insulins
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
A018006 - Hypodermic needles pen injectors
European Medical Device Nomenclature (EMDN) is the nomenclature of use by manufacturers when registering their medical devices in the EUDAMED database. EMDN is characterised by its alphanumeric structure that is established in a seven-level hierarchical tree.
A10AC01
Anatomical Therapeutic Chemical Classification according to WHOCC
0208
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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INSULIN ISOPHANE (NPH) human
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Full Name

Insulatard®(DINJINSHI1VN)

Therapeutic Action

Pancreatic hormone, antidiabetic

Intermediate-acting isophane human insulin.

Isophane insulin is made up of regular human insulin combined with NPH (Neutral Protamine Hagedornis) to delay absorption and prolong the duration of action.

Action profile:

  • onset of action: 1 - 2 hrs
  • peak action: 4 - 12 hrs
  • duration of action: 14 - 18 hrs

These action profiles are based on subcutaneous injections and are only approximations. They depend on the dose injected, the type and brand of insulin and are highly variable from one patient to another.

See Preliminary remarks on Insulins.

Indications

Diabetes

Insulin to cover basal insulin needs.

Instructions for use

Must be given as deep SC injection only.

Before using insulin for the first time, store it at room temperature for 1 or 2 hours (cold insulin is more painful).

Preparation for administration:

  • Wash hands.
  • Check the insulin vial (type and strength of insulin, expiry date) and the solution (opaque, white and aqueous).
  • Use an insulin syringe with fixed needle: 1 ml syringe graduated in 2 IU or 0.5 ml syringe graduated in 1 IU (intended for children).
  • Stir the insulin by gently rolling the vial between the palms of the hands.
  • Pull air into the syringe and inject air into the vial.
  • Draw up the required dose of insulin into the syringe.

How to administer SC insulin:

  • Insulin can be injected into the abdomen (two fingers away from the belly button), upper arm, buttocks, hips, buttocks, or the front or side of the thigh.
  • Injecting insulin in the same area repeatedly can cause lumps, swelling and thickened skin, and it may keep insulin from absorbing properly. See the picture below on “rotating” injection sites.
  • Do not inject insulin into areas that have wounds or bruising.
  • Clean the chosen injection site with soap and water. Allow to dry.
  • Pinch the skin.
  • Hold the syringe like a pencil at a 90-degree angle to the skin and insert the needle with one quick motion.
  • Inject the dose of insulin. Wait for 5 seconds before removing the needle from the skin.
  • Apply gentle pressure on the injection site with the finger for 5-10 seconds to keep insulin from leaking out.
  • Do not recap the syringe. Safety discard the needle into a sharps container.
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Precautions for Use

Mixing two types of insulin (rapid and isophane) in the same syringe should be under strict medical prescription.

It is not recommended to switch the patient from insulin type or brand (manufacturer).

The manufacturer is identified by a letter at the end of the code and the label: N = Novo Nordisk, S = Sanofi, L = Lilly.

Caution! In order to simplify ordering and the medical list, the standard is the isophane insulin from Novo Nordisk (DINJINSHI1VN).

Storage

  • Unopened vials: keep refrigerated between 2°C and 8°C - Protect from sunlight
  • Opened vials (in-use) Insulatard®: may be kept for a maximum of 4 weeks not above 25ºC.
  • Do not freeze. Discard any vial that has been frozen.
  • Keep the vial in the outer packaging.

(Cf Introduction: Thermosensitive products)