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VACCINE RABIES, CCV, cell culture, monodose, vial + diluent

https://medicalguidelines.msf.org/en/node/976
https://unicat.msf.org/cat/product/12415
STD DVACVRAB1V-

Valid Article

Former Code(s): X
The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
19.3 - Vaccines
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
J07BG01
Anatomical Therapeutic Chemical Classification according to WHOCC
E
The order of this product needs to be justified and is only acceptable under certain conditions.
0208
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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VACCINE RABIES

Therapeutic Action

Freeze-dried vaccine containing inactivated rabies virus.

Vaccine prepared from cell cultures in embryonated eggs or purified cells (CCEEVs):

  • human diploid-cells (HDCV)
  • purified Vero-cells (PVRV)
  • purified chick embryo-cells (PCEC)

Indications

Pre-exposure prophylaxis for anyone living in an isolated area where rabies risk is present and/or in a high risk area.

Post-exposure prophylaxis for anyone bitten by a suspect animal after assessment by a medical doctor.

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Instructions for use

Reconstitute the powder vial with the diluent supplied by the manufacturer.

Must be given by IM route.

For the vaccine monodose (without diluent), do not forget to order the diluent together with the vaccine!

The different CCEEV vaccines can be used interchangeably without any safety problems or loss of efficacy.

Precautions for Use

Do not administer into the gluteal muscle.

Avoid the use of vaccines prepared from animal nerve tissue (NTVs): they are less immunogenic than CCEEV vaccines and can induce severe adverse reactions.

As with all injectable vaccines and/or immunoglobulins, appropriate medical treatment should always be readily available in case of rare anaphylactic reactions following the administration of the product.

Storage

  • Do not freeze.
  • Powder: between 2°C and 8°C - Protect from sunlight
  • Diluent: if not co-packed, cold chain is not required for storage. However, at least 12 hrs before reconstitution of the vaccine, the diluent must be refrigerated between 2°C and 8°C so that the diluent and lyophilised powder are at the same temperature (a thermic shock during reconstitution would reduce the vaccine efficacy).
  • Reconstituted vaccine: use immediately.

(Cf Introduction: Thermosensitive products)