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FORMALDEHYDE (formol), 37%, 1 l, bot.

https://unicat.msf.org/cat/product/18773
STD SLASFORO3B1

Valid Article

Former Code(s): -X
12
Shelf life = length of time a product can remain active and effective. Short shelf life = shelf life = < 24 months
W01030705 - Fixing reagents (histology/cytology)
European Medical Device Nomenclature (EMDN) is the nomenclature of use by manufacturers when registering their medical devices in the EUDAMED database. EMDN is characterised by its alphanumeric structure that is established in a seven-level hierarchical tree.
UN2209
Hazardous materials and products (identified by their 4-digit transport UN-number) must be transported under certain conditions as specified in the MSDS sheet (Material Safety Data Sheet).
CT30
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
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FORMALDEHYDE (formol), 37%

Definition

Preservative used for biological products (biopsies, anatomical parts, in certain cases for stools), as well as for the formaldehyde concentration technique of parasites in stools.

In TB culture laboratories that performs MGIT liquid cultures it is used for the preparation of the formol-milk suspension.

Synonym

formol, formalin

Specifications

Technical specifications

  • Aqueous solution: 35 - 40%
  • Formula: CH2O (HCHO)
  • Stabilised with 10 to 15% of methanol
  • Mixture
    • formaldehyde (>=25% -<50% ) CAS N°50-00-0
    • ​methanol (>=10% -<20% ) CAS N° 67-56-1

Packaging & Labelling

1 litre glass or plastic bottle or 20 ml vial

Transport Dangerous Goods

  • UN2209
  • Class: 8
  • Packing group: III
  • Proper shipping name: Formaldehyde solution

Instructions for use

Never use undiluted. Prepare a 10% working solution by diluting the stock solution 1:3.

Does not store mobile vegetative forms of parasites.

Preservation and transport of biopsies

  • Follow the ratio between the biopsy's volume and the formol one (1:20).
  • Use suitable containers with screw cap (i.e. urine container: see related articles below) NB: Don't tighten too much as it may crack the container!
  • Containers containing biopsies must be identified (patient's name or code number + date and place of sampling).
  • Biopsies must be sent with clinical and epidemiological data.
  • Biopsies must be transported in a triple packaging box (see related articles below).

(Cf Procedures for transporting samples)

Usage in TB culture laboratories

  • Formol-milk suspension is used to prepare smears from positive MGIT cultures. Milk enhances adherence to the slide, which otherwise would be easily washed away during staining procedures. Formol inactivates the bacilli. Slides are used to check presence of contaminants and mycobacterial morphology from positive MGIT cultures.
  • Always follow Standard Operational Procedures.
  • The reagent can be prepared in the medium preparation room.
  • Store the solution at 2-8°C for a maximum of 12 months.
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Storage

  • Keep below 30°C, Protect from sunlight
  • Keep in a well-ventilated place
  • Tightly closed
  • Upright on the bottom shelves
  • Shelf life: 12 months
  • Guaranteed minimum remaining shelf life at delivery: 1/3 of total shelf life

Waste management

Substance with potenital carcinogenic properties (H350). Please contact your watsan referent for advice on proper disposal.

Detailed hazard and precautionary information can be found in the safety data sheet (SDS).

Classification EC Regulation N° 1272/2008

  • Acute toxicity, Oral: Category 3, H301
  • Acute toxicity, Inhalation: Category 3, H331
  • Acute toxicity, Dermal: Category 3, H311
  • Skin corrosion: Category 1B, H314
  • Skin sensitization: Category 1, H317
  • Carcinogenicity: Category 2, H351
  • Specific target organ toxicity - single exposure: Category 1, H370
  • Specific target organ toxicity - single exposure: Category 3, H335

Signal Word

Danger

Image Image Image
H301Toxic if swallowed.
H311Toxic in contact with skin.
H314Causes severe skin burns and eye damage.
H317May cause an allergic skin reaction
H330Fatal if inhaled.
H335May cause respiratory irritation
H351Suspected of causing cancer (state route of exposure if it is conclusively proven that no other routs of exposure cause the hazard).
H370Causes damage to organs (or state all organs affected, if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard).
P280Wear protective gloves/protective clothing/eye protection/face protection
P301 + P330 + P331IF SWALLOWED: rinse mouth. Do NOT induce vomiting
P302 + P352IF ON SKIN: wash with plenty of soap and water
P304 + P340IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338IF IN EYES: rinse cautiously with water for several minutes. If the victim wears contact lenses, remove them if possible. Keep rinsing
P309 + P311IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.

MSF requirements

Optimal preservation of biopsies, preferable to the Bouin liquid as the biopsies vary in size and the delivery time to the reference laboratory often takes longer than one week if located in Europe.

In TB culture laboratories, formol-milk suspension is used to prepare slides from positive MGIT liquid cultures, in order to detect presence of contaminants and acid-fast bacilli.

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