ISONIAZID, powder, 5 g [Sigma-Fluka-I3377]
Valid Article
ISONIAZID
Reserved for TB culture programmes.
Definition
Antimycobacterial used for drug susceptibility testing of M. tuberculosis complex.
Synonym
Isonicotinic acid hydrazide, INH Isonitinic hydrazide
Specifications
Technical specifications
- White powder
- Soluble in water
- Formula : C6H7N3O
- Purity : >= 99%
- CAS number: 54-85-3
- Molecular weight: 137,14 g/mol
Packaging & Labelling
5 g in glass vial
Transport not regulated
Instructions for use
For the procedure of the stock solution and working solution preparations, refer to Tuberculosis Culture Laboratory, MSF-ITM, 2014.
Avoid contact with skin and eyes.
Storage
- Store in a cool place
- Keep container tightly closed in a dry and well-ventilated place
- Avoid formation of dust and aerosols
- Provide appropriate exhaust ventilation at places where dust is formed
Waste management
Substance with hazardous characteristics. Please contact your watsan referent for advice on proper disposal.
Detailed hazard and precautionary information can be found in the safety data sheet (SDS).
Classification EC Regulation N° 1272/2008
- Acute toxicity, Oral : Category 4, H302
- Skin irritation : Category 2, H315
Signal Word
Warning
H302 | Harmful if swallowed |
H315 | Causes skin irritation |
P264 | Wash … thoroughly after handling |
P280 | Wear protective gloves/protective clothing/eye protection/face protection |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician if you feel |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water |
P332 + P313 | If skin irritation occurs: get medical advice/attention |
P362 + P364 | Take off contaminated clothing and wash it before reuse. |
MSF requirements
Isoniazid is one of the first line drugs used against M. tuberculosis complex. The test is performed to investigate resistance of the mycobacterium to this antibiotic. The drug solution is added to agar or egg-based media during preparation.