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IMMUNOGL. SNAKE ANTIVENOM, Africa (EchiTab-Plus-ICP) 10ml v.

https://unicat.msf.org/cat/product/41157
NST DVACIMAS2V-

Valid Article

Former Code(s): DVACZFR0103
The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
19.2 - Sera, immunoglobulins and monoclonal antibodies
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
J06AA03
Anatomical Therapeutic Chemical Classification according to WHOCC
F
The order of this product needs to be justified and is only acceptable under certain conditions.
0208
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)
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IMMUNOGLOBULIN SNAKE ANTIVENOM, Africa (EchiTab-Plus-ICP)

This product is not always available at supply centres level. Contact your HQ advisor and check the specifications if an alternative is offered.

Full Name

EchiTab-Plus-ICP®, Polyspecific Antivenom Liquid

Therapeutic Action

Neutralisation of snake venom

Equine immunoglobulins in liquid form

Indications

Treatment of snakebite envenomations from 25 African species found in sub-Saharan Africa, from five different genera:

  • Puff adder and Gaboon vipers (Bitis spp.)
  • African carpet vipers (Echis spp.)
  • African spitting cobras and neurotoxic cobras (Naja spp.)
  • Mambas (Dendroaspis spp.)
  • Rinkhals (Hemachatus spp.)
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Instructions for use

10 ml vial in liquid form

Posology (adults and children)

  • non-neurotoxic signs: 3 vials
  • neurotoxic signs: 9 vials
  • repeat doses may be required if there is no improvement; repeat 3 or 9 vials after 1-2 hours. Repeat again after 6 hours if necessary.

Administration

  • Adults:
    • Dilute the vials with isotonic solution (0.9% NaCl or Ringer lactate) in a 1:1 dilution ratio.
    • Administer by slow IV infusion over 30 to 60 minutes. The total volume should not exceed 500 ml/hour per dose.
    • Remark: Direct IV injection at 1 ml/min (max. 2 ml/min) should be reserved for rapidly worsening neurotoxic envenomations when a rapid bolus, with ventilatory support, can be lifesaving. It should be given with prophylactic adrenaline/epinephrine.
  • Children: avoid fluid overload
    • If 3 vials: dilute the reconstituted vials in 5 ml/kg of isotonic solution. Example for a child weighing 10 kg: total volume 50 ml = 30 ml (reconstituted serum) + 20 ml (isotonic solution).
    • If 9 vials: dilute the reconstituted vials in 10 ml/kg of isotonic solution. Example for a child weighing 10 kg: total volume 100 ml = 90 ml (reconstituted serum) + 10 ml (isotonic solution).
    • Administer by slow IV infusion without exceeding 10 to 20ml/kg in less than 1 hour, due to the risk of cardiac overload.

Refer to the Snakebite Antivenom Algorithm or contact your NTD advisor.

Precautions for Use

  • Snake antivenom must be administered intravenously. Do not administer by any other route.
  • Appropriate medical treatment must always be readily available in case of anaphylactic reactions following administration.
  • Use under medical supervision only.

Storage

  • Keep refrigerated between 2ºC and 8ºC.
  • Do not freeze.
  • After opening, use the product immediately.

(Cf Introduction: Thermosensitive products)