CARVEDILOL, 6.25mg, breakable tab.
STD
DORACARV6TB
Valid Article
Account code:
60000
HS Code:
300490
Last Updated on:
31/07/2024, 22:03:16
12.4 - Medicines used in heart failure
Classification of the medicines in groups and subgroups according to their therapeutic use.
The classification used by MSF is based on the WHO Model List of Essential Medicines.
C07AG02
Anatomical Therapeutic Chemical Classification according to WHOCC
OC subscriptions: included in supply or field order tools (e.g. UniField)
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SC subscriptions: included in supply or field tools
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OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)
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CARVEDILOL
- In the WHO list of Essential Medicines 2023 (Therapeutic alternative to bisoprolol)(1.25 and 5mg dosages)
Therapeutic Action
Vasodilatory non-selective beta-blocker
Indications
Chronic heart failure (mild to severe) in adults and children.
Left ventricular dysfunction following myocardial infarction in clinically stable patients.
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Instructions for use
Tablets should be taken with sufficient fluid.
Dosage:
- Heart failure:
- Adults: start at 3.125 mg twice daily and increase to 6.25, 12.5, and then 25 mg twice daily over intervals of at least 2 weeks. Maintain lower doses if higher doses are not tolerated.
- Children: start at 0.05 mg/kg (max 3.125 mg) twice daily and increase to 0.1, 0.2, and then 0.35 mg/kg twice daily (max 25 mg) over intervals of at least 2 weeks. Maintain lower doses if higher doses are not tolerated
- Left ventricular dysfunction following myocardial infarction:
- start at 6.25 mg twice daily and increase to 12.5 mg then 25 mg twice daily after intervals of 3 to 10 days. A lower starting dose or slower titration may be used.
Precautions for Use
Beta-blockers are contraindicated in :
- cardiogenic shock or decompensated heart failure (acute heart failure) requiring the use of diuretics or IV inotropic therapy.
- bronchial asthma or related bronchospastic conditions
- second-or third-degree AV block
- sick sinus syndrome
- severe bradycardia (unless permanent pacemaker in place)
- severe hepatic impairment.
Storage
Below 25ºC - Protect from sunlight