EPINEPHRINE (adrenaline), 0.15mg/0.3ml, auto-inject. pref.

NST DINJEPIN1AP3

Valid Article

The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
Article is intended to be used with children (<12 years) ONLY.
12.2 - Antiarrhythmic medicines
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
25.1 - Antiasthmatic medicines and medicines for chronic obstructive pulmonary disease
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
3 - Antiallergics and medicines used in anaphylaxis
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
C01CA24
Anatomical Therapeutic Chemical Classification according to WHOCC
The order of this product needs to be justified and is only acceptable under certain conditions.
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)
SC subscriptions: included in supply or field tools

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EPINEPHRINE (adrenaline) auto-injector

CAUTION

This product is worded and codified by unit (= 1 auto-injector) to make the order easier. Before ordering, check with your supply centre the unit packaging (1 or 2 auto-injectors).

Non-standard item.

Therapeutic Action

Adrenergic and dopaminergic agent, adrenaline

Indications

Emergency treatment in severe anaphylaxis, provided by medical staff in OPD settings prior to transfer to emergency department in an hospital setting.

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Instructions for use

Solution for IM injection in an auto-injector containing adrenaline injectable (1 mg/ml) in a pre-filled disposable automatic injection device, designed to deliver a single dose of 0.3 mg or 0.15 mg adrenaline when activated.

Must be given into the anterolateral part of the thigh (not in the buttock). It can be given through the clothes or directly through the skin.

Product is for single use in one patient only.

Dosage:

  • Children ≤ 15 kg: 0.15 mg epinephrine (adrenaline) equivalent to 150 mcg adrenaline
  • Children > 15 kg and adults: 0.3 mg epinephrine (adrenaline) equivalent to 300 mcg adrenaline
  • Repeat same dose 1-2 times every 5-15 minutes (max 3 boluses) if no clinical improvement.

Caution! always check the dosage indicated on the cartridge.

Method of administration:

  • Grasp the auto-injector in dominant hand, with thumb nearest safety cap.
  • With other hand pull off safety cap by pulling it upwards.
  • Hold the auto-injector approximately 10 cm from the outer thigh. The injection tip should point towards the outer thigh.
  • Push the auto-injector firmly into the outer thigh at a right angle (90°). When the auto-injector is pushed into the thigh, a spring-loaded plunger is released, which pushes the hidden needle into the thigh muscle to deliver a dose of adrenaline.
  • Hold the auto-injector firmly against the thigh for 3-10 seconds (depends of the model). The injection is now complete and the fluid control window of the auto-injector appears opaque.
  • Remove the auto-injector.
  • Massage the injection area for 10 seconds.
  • Discard the auto-injector immediately after use. After activation, even through most of the liquid remains in the auto-injector, it cannot be reused.

The instructions for use are included in the packaging and must be carefully followed.

A trainer pen without needle or adrenaline for practising or instructing others in the correct use of epinephrine auto-injector is available (ETMECLISAI1).

MSF selected 3 auto-injector brands for both dosages (150 and 300 mcg): AnaPen®, Epipen®, Jext®. Codes are the same independently of the manufacturer brand. See below instructions for use according the model.

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Precautions for Use

Never put thumb, fingers or hand over the injection tip.

Do not remove the safety cap until ready to use.

A small air bubble may be present in the auto-injector. It does not affect the way the product works.

Storage

  • Below 25ºC - Protect from sunlight
  • Do not refrigerate or freeze.
  • Keep container in the outer carton in order to protect from light.
  • Do not use the auto-injector if the solution is unclear, discoloured or contains solid particles (precipitate).
  • Shelf life:
    • Anapen®: 24 months / Anapen Junior® : 21 months
    • EpiPen®: 24 months / EpiPen Junior®: 19 months
    • Jext®: 22 months
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