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AMPHOTERICIN B conventional, 50mg, powder, vial

https://medicalguidelines.msf.org/en/node/737
https://unicat.msf.org/cat/product/11616
STD DINJAMBC5V-

Valid Article

Former Code(s): DINJAMPH5VC
The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
6.3 - Antifungal medicines
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
6.5.2 - Antileishmaniasis medicines
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
J02AA01
Anatomical Therapeutic Chemical Classification according to WHOCC
P
The order of this product needs to be justified and is only acceptable under certain conditions.
0208
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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AMPHOTERICIN B conventional

Therapeutic Action

Antifungal medicine

Indications

Cryptococcal meningitis (induction phase)

Severe histoplasmosis or penicilliosis

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Instructions for use

Reconstitute the powder vial with 10 ml of water for injection to obtain a concentrated solution at 5 mg/ml amphotericin B.

Dilute the concentrated solution in 500 ml of 5% glucose to obtain a solution at 0.1 mg/ml amphotericin B for slow IV infusion.

The liposomal amphotericin B (AmBisome®) is better absorbed and has less risk of renal toxicity than the conventional amphotericin B (Fungizone®) for the treatment of cryptococcal meningitis.

Precautions for Use

For slow IV infusion, use only 5% glucose (not compatible with other infusion fluids).

Storage

  • Powder: between 2ºC and 8°C. In the absence of a refrigerator, can be stored for 7 days maximum below 25°C.
  • Concentrated solution (5 mg/ml): keep refrigerated between 2ºC and 8°C for 24hrs maximum. Do not freeze.
  • Solution for infusion (0.1 mg/ml): use immediately. Protect from sunlight

(Cf Introduction: Thermosensitive products)