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ISONIAZID (H), 100mg, breakable tab., blister

https://medicalguidelines.msf.org/en/node/422
https://unicat.msf.org/cat/product/12096
STD DORAISON1TB1

Valid Article

Former Code(s): DORAISON1T- DORAISON1T1 Z
Article is intended to be used with children (<12 years) ONLY.
6.2.5 - Antituberculosis medicines
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
J04AC01
Anatomical Therapeutic Chemical Classification according to WHOCC
S
The order of this product needs to be justified and is only acceptable under certain conditions.
1525
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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ISONIAZID (H)

Therapeutic Action

Antituberculosis bactericide

Indications

Drug-Resistant Tuberculosis (DR-TB), in combination with other TB medicines

Drug-Sensitive Tuberculosis (DS-TB)

Latent Tuberculosis Infection (LTI-TB)

Instructions for use

The 100 mg dispersible tablet replaces the 100 mg breakable tablet.

The 50 mg and 100 mg dispersible tablets are intended for paediatric use. To be dispersed in 10 ml water.

Must be given without food.

It is recommended to administer pyridoxine (Vit B6) PO in patients at risk (HIV, malnutrition, pregnant and breastfeeding women, breast-fed infants) to prevent isoniazid-related peripheral neuropathy.

Blister packaging is the packaging of choice for antituberculosis medicines due to the unstable nature of some of them when exposed to higher temperatures and humidity.

Bulk packaging (hospital packs) should only be used in special circumstances or in case of unexpected problems in availability of the blister presentation.

The quantity to be ordered is calculated per tablet, not per blister.

When isoniazid is used in association with other TB medicines, fixed-dose combinations (FDC) are available:

  • E 275mg / H 75mg / Z 400mg / R 150mg, tab., blister
  • H 50mg / Z 150mg / R 75mg, disp. tab., blister
  • E 275mg / H 75mg / R 150mg, tab., blister
  • H 50mg / R 75mg, disp. tab., blister
  • H 75mg / R 150mg, tab., blister
  • ISONIAZID 300mg / RIFAPENTINE, 300mg, tab., blister

Precautions for Use

Do not administer in case of severe hepatic impairment.

Storage

Below 25ºC ‐ Protect from sunlight ‐ Protect from humidity