PHYTOMENADIONE (vitamin K1), 10mg/ml, 1ml, amp.


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10.2 - Medicines affecting coagulation
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
Anatomical Therapeutic Chemical Classification according to WHOCC
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
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Therapeutic Action

Vitamin K, anti-haemorrhagic


Prophylaxis and treatment of haemorrhagic disease of the newborn

Instructions for use

Two presentations of phytomenadione are available for different indications:

  • Oral: 10mg/ml solution in 1ml ampoule. It is recommended to give vitamin K1 (10 mg/day PO) to pregnant women on rifampicin treatment during the last two weeks of pregnancy to prevent haemorrhagic disease of the newborn.
  • Injectable: 10mg/ml solution in 0.2 ml ampoule (= 2 mg/amp). Indicated for the prevention and treatment of haemorrhagic disease of the newborn.

Both presentations are mixed micelles solutions and are supplied with an oral dosing syringe.

Mixed micelles are composed of glycocholic acid (bile acid) and lecithin in an aqueous solution allowing solubilization of the vitamin K and, therefore, an oral absorption equivalent to that by injectable route.

For this reason, both presentations can be administered either by ORAL or INJECTABLE route.


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