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PHYTOMENADIONE (vitamin K1), 10mg/ml, 1ml, amp.

https://medicalguidelines.msf.org/en/node/915
https://unicat.msf.org/cat/product/12247
STD DORAPHYT1A1

Valid Article

Former Code(s): -X
10.2 - Medicines affecting coagulation
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
B02BA01
Anatomical Therapeutic Chemical Classification according to WHOCC
1525
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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PHYTOMENADIONE (vitamin K1)

Therapeutic Action

Vitamin K, anti-haemorrhagic

Indications

Prophylaxis and treatment of haemorrhagic disease of the newborn

Instructions for use

Two presentations of phytomenadione are available for different indications:

  • Oral: 10mg/ml solution in 1ml ampoule. It is recommended to give vitamin K1 (10 mg/day PO) to pregnant women on rifampicin treatment during the last two weeks of pregnancy to prevent haemorrhagic disease of the newborn.
  • Injectable: 10mg/ml solution in 0.2 ml ampoule (= 2 mg/amp). Indicated for the prevention and treatment of haemorrhagic disease of the newborn.

Both presentations are mixed micelles solutions and are supplied with an oral dosing syringe.

Mixed micelles are composed of glycocholic acid (bile acid) and lecithin in an aqueous solution allowing solubilization of the vitamin K and, therefore, an oral absorption equivalent to that by injectable route.

For this reason, both presentations can be administered either by ORAL or INJECTABLE route.

Storage

Below 25°C - Protect from sunlight