ETHIONAMIDE, powder, 5 g [Sigma-E6005.5G]

STD SASTAPWDETI5

Valid Article

Former Code(s): SLASETHN5P- SLASZNL0083 -X
W0104010699 - Media for mycobacteria cultures - manual & automated (for ast drugs , supplements) - other
European Medical Device Nomenclature (EMDN) is the nomenclature of use by manufacturers when registering their medical devices in the EUDAMED database. EMDN is characterised by its alphanumeric structure that is established in a seven-level hierarchical tree.
The order of this product needs to be justified and is only acceptable under certain conditions.
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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ETHIONAMIDE

Reserved for TB culture programmes.

Definition

Antimycobacterial used for drug susceptibility testing of M. tuberculosis complex.

Synonym

2-Ethyl-4 pyridinecarbothioamide

Specifications

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Technical specifications

  • Yellow powder
  • White to off-white, in solution colourless to faint yellow
  • Clear yellow solution at 50 mg/ml in Pyridine
  • ​C8H10N2S
  • Mocecular weight: 166.24 g/mol
  • CAS No: 536-33-4

Packaging & Labelling

5 g in glass vial

Transport not regulated

Instructions for use

  • For the procedure of stock solution and working solution preparations, refer to Tuberculosis Culture Laboratory, MSF-ITM, 2014.
  • ​The drug working solution is added to the medium during preparation (agar or LJ) or prior to inoculation (MGIT broth tubes).
  • Avoid contact with skin and eyes.

Storage

  • Keep refrigerated between 2º C and 8º C. Do not freeze
  • Keep container tightly closed in a dry and well-ventilated place.
  • Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed

(Cf Introduction: Thermosensitive products)

Waste management

Substance with hazardous characteristics. Please contact your watsan referent for advice on proper disposal.

Detailed hazard and precautionary information can be found in the safety data sheet (SDS).

Classification EC Regulation N° 1272/2008

  • Acute toxicity, Oral: Category 4, H302
  • Reproductive toxicity: Category 2, H361
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Signal Word

Warning

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child (route of exposure if it is conclusively proven that no other routes of exposure cause the hazard).
P202Do not handle until all safety precautions have been read and understood.
P270Do not eat, drink or smoke when using this product.
P264Wash … thoroughly after handling
P280Wear protective gloves/protective clothing/eye protection/face protection
P301 + P312IF SWALLOWED: call a POISON CENTER or doctor/physician if you feel
P308 + P313IF exposed or concerned: Get medical advice/attention.

MSF requirements

Ethionamide is part of the second line drugs used against M. tuberculosis complex. The test is performed to investigate resistance of the mycobacteria to this antibiotic. ​It can be used for liquid and solid cultures.

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