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KANAMYCIN sulfate, powder, 1 g [Sigma-K1377-1G]

<a class="fmCATtoTB" target="_blank" href="https://medicalguidelines.msf.org/viewport/TUB/english/8-5-cross-resistance-20321543.html">KANAMYCIN</a>
https://unicat.msf.org/cat/product/18796
NST SASTAPWDKAN1

Valid Article

Former Code(s): SLASKANA1-- SASTAPWD1--
P
The order of this product needs to be justified and is only acceptable under certain conditions.
CT25
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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KANAMYCIN

Article became NST in 2021 - No longer part of the drug susceptibility testing of M. tuberculosis complex.

Reserved for TB culture programmes.

Definition

Antimycobacterial used for drug susceptibility testing of M. tuberculosis complex.

Synonym

Kanamycin A, Kanamycin sulfate salt.

Specifications

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Technical specifications

  • Powder
  • White to Off-White, in solution colorless to faint yellow
  • Soluble in water
  • Formula: C18H36N4O11.H2O4S
  • Purity: ≥ 750µg per mg

Packaging

1 g in glass bottle

Transport not regulated

Instructions for use

  • Avoid exposure - obtain special instructions before use.
  • For the procedure of stock solution and working solution preparations, refer to Tuberculosis Culture Laboratory, MSF-ITM, 2014.
  • The drug working solution is added to the medium during preparation (agar or LJ) or prior to inoculation (MGIT broth tubes).

Storage

  • Store powder at room temperature
  • Prepared solutions are stable for 5 days at 37°C
  • Aqueous stock solutions can be stored at 2-8 °C
  • Keep container tightly closed in a dry and well-ventilated place
  • Avoid formation of dust and aerosols
  • Provide appropriate exhaust ventillation at places where dust is formed

Classification EC Regulation N° 1272/2008

  • Reproductive toxicity: Category 1B, H360

Signal Word

Danger

H360May damage fertility or the unborn child (state specific effect if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard)
P201Obtain special instructions before use.
P308 + P313IF exposed or concerned: Get medical advice/attention.

MSF requirements

Kanamycin is part of the second line drugs used against M. tuberculosis complex. The test is performed to investigate resistance of the mycobacteria to this antibiotic. It can be used for liquid and solid cultures.

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