RIBAVIRIN, 200mg, tab.
Valid Article
RIBAVIRIN
Therapeutic Action
Antiviral
Indications
Aetiological treatment of Lassa fever and Crimean-Congo fever
Second-line treatment (re-treatment) of chronic hepatitis C virus (HCV) in selected countries, in combination with direct-acting antivirals (DAAs) such as sofosbuvir/velpatasvir.
- See: Clinical guidelines, MSF, 2024
- See: Hepatitis C Care, Implementation guidance for the field teams, MSF 2024
Instructions for use
For the re-treatment of HCV, ribavirin should always be used in combination with a direct-acting antiviral (DAA) containing sofosbuvir, such as the combination of sofosbuvir/daclastavir.
Due to the frequent dose adjustments required to manage ribavirin-related side effects, the 200 mg concentration is preferred.
Precautions for Use
Contraindicated in patients with anaemia, severe cardiac disease, haemoglobinopathies, renal impairment
Do not administer in pregnant women (and until 5 months after delivery)
Caution!
Ribavirin is teratogenic and passes into semen. Pregnancy should be excluded before initiation treatment. Effective contraception is essential during treatment and for six months after treatment in females of childbearing age and in males sexually active. Routine monthly pregnancy tests are recommended.
Storage
Below 25ºC