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VANCOMYCIN hydrocloride, eq. 500mg base, powder, vial

https://unicat.msf.org/cat/product/48775
STD DINJVANC5V-

Valid Article

Former Code(s): DINJZBE0003
The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
6.2.2 - Watch group antibiotics
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
J01XA01
Anatomical Therapeutic Chemical Classification according to WHOCC
P
The order of this product needs to be justified and is only acceptable under certain conditions.
1525
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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VANCOMYCIN

Therapeutic Action

Glycopeptide antibacterial

Indications

Treatment of Gram-positive infections (staphylococci, streptococci including pneumococci, enterococci).

Surgical prophylaxis in some contexts where high prevalence of MRSA exist.

Vancomycin has no activity against Gram-negative bacteria.

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Instructions for use

Reconstitute the 1 g powder vial with 20 ml of water for injection (the 500 mg vial with 10 ml of water for injection) to obtain a reconstituted solution at 50 mg/ml vancomycin.

The reconstituted solution must be given as slow IV infusion (10 mg/min) in at least 200 ml of 0.9% NaCl or 5% dextrose. The solution should be clear.

Monitor regularly haematologic levels, creatinemia, liver and renal function.

When feasible, therapeutic dose monitoring for vancomycin is recommended.

Precautions for Use

Do not administer by IM route (risk of necrosis at the injection site).

Only administer by slow IV infusion to prevent infusion-related adverse effects. Rapid bolus administration may result in hypotension, histamine like responses and maculopapular or erythematous rash (“red man's syndrome” or “red neck syndrome”). Stopping the infusion usually results in a prompt cessation of these reactions.

Avoid association with other neurotoxic and/or nephrotoxic drugs (gentamycin, amphotericin B, streptomycin, amikacin, piperacillin/tazobactam, cisplatin) which may potentiate the nephrotoxicity and/or ototoxicity of vancomycin.

Administer with caution in patients with impaired renal function.

Do not administer during pregnancy unless the benefits outweigh the risks of the medication.

Storage

  • Below 25ºC - Protect from sunlight
  • After reconstitution and dilution, use the solution immediately; discard any unused open vial.