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DOXORUBICIN HCl, pegylated liposomal, 2mg/ml, 10ml vial

https://unicat.msf.org/cat/product/11670
NST DINJDOPL2V-

Valid Article

The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
18
Shelf life = length of time a product can remain active and effective. Short shelf life = shelf life = < 24 months
8.2.1 - Cytotoxic medicines
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
L01DB01
Anatomical Therapeutic Chemical Classification according to WHOCC
M
The order of this product needs to be justified and is only acceptable under certain conditions.
0208
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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DOXORUBICIN pegylated liposomal

Therapeutic Action

Anthracycline cytotoxic

Doxorubicin hydrochloride encapsulated in liposomes with methoxypolyethylene glycol (MPEG) on the surface. This process is known as pegylation and protects the liposomes from detection by the mononuclear phagocytic system (MPS), thereby increasing their duration in the blood.

Indications

Ovarian cancer

Kaposi's sarcoma in HIV patients

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Instructions for use

Must be given as IV infusion in 5% dextrose, via the tubing of an IV infusion dedicated to doxorubicin.

Ensure that the doxorubicin is administered intravenously into a large vein to minimise the risk of thrombosis or perivenous extravasation (risk of necrosis of surrounding tissue).

Precautions for Use

Do not mix with heparin (risk of precipitate).

Contraindicated during pregnancy.

Advise women of childbearing age to use effective contraception during treatment with doxorubicin and for 6 months after the last dose.

Cytotoxic medicine!

  • Dangerous substance for the staff handling it.
  • Cytotoxic drugs should not be handled or administered by pregnant staff members.
  • It is mandatory to train the staff and to follow the Standard Precautions during preparation, reconstitution, dispensation, stock management and disposal : wear gloves, gown with long sleeves, protective glasses, respirator, etc.

(See introduction: Cytotoxic drugs in the MSF Supply Chain)

Storage

  • Keep refrigerated between 2ºC and 8ºC - Protect from sunlight
  • Do not freeze.
  • Shelf life: 18 months
  • Any unused solution should be discarded.

(Cf Introduction: Thermosensitive products)