ENOXAPARIN sodium, 10,000 IU/1ml, syr.

• In the WHO list of Essential Medicines 2023

Anticoagulant, low molecular weight heparin (LMWH)

Prevention and treatment of venous thromboembolic disease in adults

Pre-filled syringe at :

• 10,000 IU = 100 mg enoxaparin sodium in 1 ml WPI
• 2,000 IU = 20 mg enoxaparin sodium in 0.2 ml WPI
• 4,000 IU = 40 mg enoxaparin sodium in 0.4 ml WPI
• 6,000 IU = 60 mg enoxaparin sodium in 0.6 ml WPI

Equivalences:

• Enoxaparin 0.2 ml (2000 UI) = Nadroparin 0.3 ml (2850 UI)
• Enoxaparin 0.4 ml (4000 UI) = Nadroparin 0.4 ml (3800 UI)
• Enoxaparin 0.6 ml (6000 UI) = Nadroparin 0.6 ml (5700 UI)

Must be given as deep SC injection:

• Administer preferably with the patient in the supine position, in the subcutaneous cellular tissue of the anterolateral and posterolateral abdominal belt, alternating between the right and left sides.
• Remove the protective cap from the needle.
• Do not expel the air bubble from the syringe.
• If a drop appears at the tip of the needle, remove the drop before injection by tapping on the body of the syringe (needle pointing downwards).
• Insert the entire length of the needle perpendicularly and not tangentially, into a skin fold gently held between the thumb and index finger. Maintain the skin fold throughout the injection.
• Do not rub the injection site after administration.
• Immediately dispose of the syringe in the appropriate container. Any unused medication should be discarded.

Monitor coagulation parameters in order to adjust dose.

Check platelet counts before starting treatment and then twice a week.

Effects may be reversed by the slow IV administration of protamine, a specific heparin antagonist.