MANNITOL, 20%, 500ml, semi-rigid bot., PVC free
Valid Article
MANNITOL
Therapeutic Action
Osmotic diuretic
Indications
Raised intracranial hypertension in traumatic brain injury patients
Cerebral oedema
Instructions for use
Must be given as slow IV infusion.
Never administer by IM or SC route.
Use a filter for IV line because of the risk of crystal formation with mannitol.
Precautions for Use
Contraindicated in patients with abnormal capillary fragility, pulmonary congestion or pulmonary oedema, intracranial bleeding, congestive heart failure and renal failure unless a test dose has produced a diuretic response.
Remark
Mannitol is a saturated solution, which may occasionally crystallise:
- Do not administer mannitol if the solution contains crystals.
- Thoroughly check the solution for crystals immediately before use.
- If necessary, redissolve the crystals by heating the solution to 60°C in a water bath, shaking regularly until the crystals are redissolved.
- Keep the bottle upright in water while heating. Do not immerse in water (cover the top).
- Do not heat in microwave.
- Allow the solution to cool to room temperature before administering.
In case of local purchase, flexible bags are preferred to semi-rigid bottles. Contact your OC pharmacist for validation and approval.
Storage
- Bellow 25ºC.
- Do not refrigerate.
- Do not freeze.
- After opening, use the product immediately.
Caution!
It is important to pay attention to stack-piling, handling and internal transport conditions to prevent compression of the secondary packaging which could lead to micro-leakage of the bottle/bag (risk of microbial contamination).