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AZITHROMYCIN, 500mg, powder, vial

https://unicat.msf.org/cat/product/80352
STD DINJAZIT5V-

Valid Article

The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
6.2.2 - Watch group antibiotics
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
J01FA10
Anatomical Therapeutic Chemical Classification according to WHOCC
PF
The order of this product needs to be justified and is only acceptable under certain conditions.
1525
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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AZITHROMYCIN

Therapeutic Action

Anti-infective for systemic use

Macrolide antibiotic

Indications

First-line treatment of severe respiratory diphtheria when oral treatment is not possible.

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Instructions for use

Reconstitute the 500 mg powder vial with 4.8 ml of water for injection to obtain a reconstituted solution at 100 mg/ml azithromycin.

Shake the vial until complete dissolution of the contents. The reconstituted solution must be clear and free of visible particles.

Dilute the reconstituted solution in 250 or 500 ml of 0.9% NaCl, 5% dextrose or Ringer Lactate to obtain a concentration at 1.0 or 2 mg/ml azithromycin.

The diluted solution must be given as slow IV infusion (over 60 min):

  • Children: 10-12 mg/kg (max. 500 mg/d), once daily
  • Adults: 500 mg, once daily

Switch to oral azithromycin as soon as the patient can swallow, until the full course of treatment (14 days) is completed.

IV azithromycin is much better tolerated by patients than IV erythromycin and it is administered once daily.

Precautions for Use

Do not administer as an IV bolus or IM injection.

Contraindicated in patients with hypersensitivity to azithromycin, erythromycin or any of the macrolide or ketolide antibiotics.

Do not administer in children < 6 weeks of age.

Storage

  • Below 25°C ‐ Protect from sunlight ‐ Protect from humidity
  • After reconstitution and dilution, use the solution immediately.