ISONIAZID (H), 100mg, disp. tab., blister
Valid Article
ISONIAZID (H)
Therapeutic Action
Antituberculosis bactericide
Indications
Drug-Resistant Tuberculosis (DR-TB), in combination with other TB medicines
Drug-Sensitive Tuberculosis (DS-TB)
Latent Tuberculosis Infection (LTI-TB)
- See: Essential drugs, MSF, 2024
- See: WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Drug-Resistant Tuberculosis Treatment, WHO, 2020
- See: Guidelines for treatment of drug-susceptible tuberculosis , WHO, 2017
- See: WHO consolidated guidelines on tuberculosis: module 1: prevention: tuberculosis preventive treatment, WHO, 2020
- See: Tuberculosis, MSF, 2024
Instructions for use
The 100 mg dispersible tablet replaces the 100 mg breakable tablet.
The 50 mg and 100 mg dispersible tablets are intended for paediatric use. To be dispersed in 10 ml water.
Must be given without food.
It is recommended to administer pyridoxine (Vit B6) PO in patients at risk (HIV, malnutrition, pregnant and breastfeeding women, breast-fed infants) to prevent isoniazid-related peripheral neuropathy.
Blister packaging is the packaging of choice for antituberculosis medicines due to the unstable nature of some of them when exposed to higher temperatures and humidity.
Bulk packaging (hospital packs) should only be used in special circumstances or in case of unexpected problems in availability of the blister presentation.
The quantity to be ordered is calculated per tablet, not per blister.
When isoniazid is used in association with other TB medicines, fixed-dose combinations (FDC) are available:
- E 275mg / H 75mg / Z 400mg / R 150mg, tab., blister
- H 50mg / Z 150mg / R 75mg, disp. tab., blister
- E 275mg / H 75mg / R 150mg, tab., blister
- H 50mg / R 75mg, disp. tab., blister
- H 75mg / R 150mg, tab., blister
- ISONIAZID 300mg / RIFAPENTINE, 300mg, tab., blister
Precautions for Use
Do not administer in case of severe hepatic impairment.
Storage
Below 25ºC ‐ Protect from sunlight ‐ Protect from humidity