ARTESUNATE 60mg, pwd vial + ARGININE 2%/NaHCO3 0.84% 3ml amp

STD DINJARTS6V3

Valid Article

Former Code(s): DINJARTS6V7

The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
P01BE03
Anatomical Therapeutic Chemical Classification according to WHOCC
The order of this product needs to be justified and is only acceptable under certain conditions.
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.

OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

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ARTESUNATE + ARGININE

CAUTION!

To ensure a smooth transition between both artesunate formulations (DINJART6V- and DINJARTS6V3), estimate the forecast and assess the manufacturer's production capacity, this product is reserved for Nigeria, CAR and DRC missions for one year.

Therapeutic Action

Antimalarial, artemisinine derivative

Indications

Severe malaria caused by Plasmodium falciparum

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Instructions for use

Combi-pack including:

  • 1 powder vial containing 60 mg of artesunate
  • 1 ampoule with 3 ml of 0.84% (8.4mg/ml) sodium bicarbonate (NaHCO3) + 2% (20mg/ml) arginine for reconstitution

The new artesunate formulation eliminates the need for separate reconstitution and dilution of the powder. It simplifies and speeds up administration, reducing the risk of preparation errors.

For instructions on reconstitution and administration, refer to Injectable Artesunate FOR SEVERE MALARIA ONLY (see related articles).

ARTESUNATE 60 mg with arginine (DINJARTS6V3), uses the same weight-based dosing as ARTESUNATE 60 mg without arginine (DINJARTS6V-).

Must be given as a slow IV or IM injection.

Remark: The missions should first finish the remaining stock of artesunate without arginine (DINJARTS6V-) before ordering this new formulation. Having both formulations simultaneously at field level is discouraged.

Precautions for Use

Never administer by IV infusion.

Do not reconstitute the artesunate powder with water for injection. Use the diluents provided in the 3 ml ampoule.

Storage

  • Below 25ºC - Protect from sunlight
  • After reconstitution, use the solution immediately.
  • Do not refrigerate or freeze.