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ARTESUNATE 60mg, pwd vial + ARGININE 2%/NaHCO3 0.84% 3ml amp

https://medicalguidelines.msf.org/en/node/745
https://unicat.msf.org/cat/product/92766
NST DINJARTS6V3

Valid Article

Former Code(s): DINJARTS6V7
The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
6.5.3.1 - For curative treatment
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
P01BE03
Anatomical Therapeutic Chemical Classification according to WHOCC
1525
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)

This combination does not exist.

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ARTESUNATE + ARGININE

Therapeutic Action

Antimalarial, artemisinine derivative

Indications

Severe malaria caused by Plasmodium falciparum

Instructions for use

Combi-pack containing:

  • 1 powder vial of 60 mg artesunate
  • 1 ampoule containing 3 ml of 0.84% (8.4 mg/ml) sodium bicarbonate (NaHCO3) + 2% (20 mg/ml) arginine for reconstitution

This new formulation of artesunate means there is no need to separately reconstitute and then dilute the artesunate powder. It allows to administer artesunate in a simplest and faster way with less risk of preparation errors.

Refer to the instructions detailed in Injectable artesunate FOR SEVERE MALARIA ONLY (see articles related) for reconstitution and administration.

ARTESUNATE 60mg, powder,vial + NaHCO3 5% 1ml + NaCl 0.9% 5ml (DINJARTS6V-) and ARTESUNATE 60mg, pwd vial + ARGININE 2%/NaHCO3 0.84% 3ml (DINJARTS6V3) are interchangeable and weight-dosing is the same. Missions should progressively shift from DINJARTS6V- to DINJARTS6V3.

Must be given as slow IV or IM injection.

Precautions for Use

Never administer by IV infusion.

Do not use water for injection for reconstitution of the artesunate powder. Use the diluents contained in the 3 ml ampoule provided.

Storage

  • Below 25ºC - Protect from sunlight
  • After reconstitution, use the solution immediately.
  • Do not refrigerate or freeze.